Strain |
Burkholderia mallei ATCC 23344
GCF_000011705.1|latest |
Locus Tag |
BMAA1523
|
Name |
bopE
|
Replicon | chromosome 2 |
Genomic location | 1652361 - 1653146 (+ strand) |
Comment | This gene is part of the Burkholderia mallei type III secretion system T3SS-3 gene locus. |
RefSeq | YP_106114.1 |
GI | 53716481 |
NCBI Locus Tag | BMAA1523 |
RefSeq | YP_106114.1,GeneID |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
guanine nucleotide exchange factor BopE (T3SS-3)
|
Synonyms |
type III secretion target BopE |
Evidence for Translation | |
Charge (pH 7) | 8.14 |
Kyte-Doolittle Hydrophobicity Value | -0.553 |
Molecular Weight (kDa) | 28735.0 |
Isoelectric Point (pI) | 9.89 |
Individual Mappings | |
Additional evidence for subcellular localization |
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
2JOK | CELL INVASION, SIGNALING PROTEIN | 03/14/07 | NMR structure of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei | BURKHOLDERIA PSEUDOMALLEI | NOT | SOLUTION NMR | 99.5 |
2JOL | CELL INVASION, SIGNALING PROTEIN | 03/14/07 | Average NMR structure of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei | BURKHOLDERIA PSEUDOMALLEI | NOT | SOLUTION NMR | 99.5 |
Source 1 | |
Database | VFDB : VF0428 |
Category | T3SS-3 |
Evidence |
ECO:0000250
sequence similarity evidence used in manual assertion
|
Host Organism | |
Notes | |
Annotation transferred from | Burkholderia pseudomallei K96243 |
Reference | 17984080 |
Results | Analysis not done |
Burkholderia Ortholog Group |
BG019825 (316 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BMAA1523
Search term: bopE
Search term: guanine nucleotide exchange factor BopE (T3SS-3)
|
The guanine-nucleotide-exchange factor BopE from Burkholderia pseudomallei adopts a compact version of the Salmonella SopE/SopE2 fold and undergoes a closed-to-open conformational change upon interaction with Cdc42.
Upadhyay A, Wu HL, Williams C, Field T, Galyov EE, van den Elsen JM, Bagby S
Biochem J 2008 May 1;411(3):485-93
PubMed ID: 18052936
|
Inactivation of Burkholderia pseudomallei bsaQ results in decreased invasion efficiency and delayed escape of bacteria from endocytic vesicles.
Muangsombut V, Suparak S, Pumirat P, Damnin S, Vattanaviboon P, Thongboonkerd V, Korbsrisate S
Arch Microbiol 2008 Dec;190(6):623-31
PubMed ID: 18654761
|
Caspase-1-dependent and -independent cell death pathways in Burkholderia pseudomallei infection of macrophages.
Bast A, Krause K, Schmidt IH, Pudla M, Brakopp S, Hopf V, Breitbach K, Steinmetz I
PLoS Pathog 2014 Mar;10(3):e1003986
PubMed ID: 24626296
|
A live experimental vaccine against Burkholderia pseudomallei elicits CD4+ T cell-mediated immunity, priming T cells specific for 2 type III secretion system proteins.
Haque A, Chu K, Easton A, Stevens MP, Galyov EE, Atkins T, Titball R, Bancroft GJ
J Infect Dis 2006 Nov 1;194(9):1241-8
PubMed ID: 17041850
|
Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268
|
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152
|